About Image


      Bone Biologics is a publicly traded company based in Burlington, MA and is focused on developing and marketing orthobiologic products. Our proprietary platform technology is NELL-1, a recombinant human protein growth factor that is essential for normal bone development. Our lead product is a NELL-1 based bone graft substitute for spine fusion, targeting the rapidly growing orthobiologics market. Our goal is to offer patients superior safety with uncompromising efficacy relative to existing technologies. NELL-1  provides specific targeted regulation over bone regeneration in the presence of targeted osteogenic cells, as both demonstrated in the lab and through the use of animal testing, unlike any other current therapy. It has been shown not to form bone when applied to non-osteogenic cells such as myoblasts (a type of embryonic progenitor cell that differentiates to give rise to muscle cells) nor does it induce adipogenesis (the formation of fat that can occur within the bone matrix often exhibited as cysts) that results in weaker bone.

      Our mission is to utilize the power of NELL-1 to improve clinical outcomes and reduce total health care delivery costs associated with spinal fusion. Bone Biologics is focused on bone repair and regeneration applications and is committed to exploring additional applications of the NELL-1 technology to enhance bone regeneration and repair in areas where the current options provide suboptimal patient outcomes.


      Leadership Image


          The Bone Biologics leadership team consists of some of the top leaders and innovators of orthobiologics in regenerative medicine. Not only does our leadership provide strategic oversight of the Company, they contribute to the collective advancement of the industry. This leadership is instrumental in fulfilling our mission to improve clinical outcomes and reduce health care delivery costs associated with lumbar spinal fusion.


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          Market Overview

          The global orthobiologics market is valued at approximately $3 billion in 2016 and growing at mid-single digit growth rates (Source: Orthopedic Network News). While the product is initially targeted at the spine fusion market, Bone Biologics believes the NELL-1/DBX fusion device's unique set of characteristics including target specific mechanism of action, efficacy, safety, and affordability position the product well for application in a variety of procedures, including:

          Non-Union Trauma Cases – While the majority of fractures heal without the need for osteosynthetic products, bone substitutes are used in complicated breaks where the bone does not mend naturally. The NELL-1/DBX fusion device is expected to perform as effectively as high-priced growth factors in this market

          Hip & Knee Revisions – The use of bone substitutes in reconstruction surgery is generally limited to revision cases where the products are used to account for the significant bone loss that accompanies these cases. Hip and knee reconstruction for osteoporotic patients is a substantial opportunity for the NELL-1/DBX fusion device.

          International Markets – The company is currently focused on the domestic United States market, but recognizes the potential of international markets where specific country demographics may be similar to that of the United States.

          Investor Relations

          Investor Relations Image

              Investor Relations

              Bone Biologics was founded in 2004 by Dr. Chia Soo, MD/Vice-Chair and Professor, UCLA Hospital Dept of Orthopedic Surgery; Dr. Kang Ting DMD, DMSc/Professor, UCLA Dental School; and Dr. Benjamin Wu, DDS, PhD/Chair and Professor, UCLA Dept of Bioengineering.The Company was acquired in 2006 by MTF, the major shareholder and primary funder since the acquisition.

              Headquartered in Burlington, Massachusetts, USA, Bone Biologics became a public company in September 2014 and is focused on bone repair and regeneration applications. The company is committed to exploring additional applications of the NELL-1 technology to enhance bone regeneration and repair in areas where the current options provide suboptimal patient outcomes.


              Contact Image


                  General Inquiries:
                  Chris Martin
                  412.749.9299 x2

                  Investor Inquiries:
                  Mark Collinson

                  Media Inquiries:
                  Tracy Williams
                  310.824.9000 x22

                  For information regarding our company and/or products, please complete the form below.

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